欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Mineralocorticoid Receptor (MLR)-Finerenone
Finerenone

Chemical Structure : Finerenone

CAS No.: 1050477-31-0

加入收藏

Finerenone (BAY 94-8862, BAY 948862)

货号: PC-63433Not For Human Use, Lab Use Only.

Finerenone (BAY 94-8862) is a potent, selective, orally available mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM.

规格 价格 库存 数量
5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3680 In stock
100 mg ￥5680 In stock
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Finerenone (BAY 94-8862) is a potent, selective, orally available mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM.
Finerenone (BAY 94-8862) displays excellent selectivity (>500-fold) versus GR, AR, and PR, also shows no L type Ca2+ channel activity.
Finerenone (BAY 94-8862) elicits a significant and dose-dependent increase in the urinary sodium/potassium ratio in vivo, with a MED of 0.3 mg kg1 p.o.
Finerenone (BAY 94-8862) exhibits three- to tenfold greater potency and higher efficacy in acute rat natriuresis model compared with eplerenone, demonstrates potential for the treatment of chronic heart failure (CHF).

物理化学性质&存储条件

分子量 378.432
分子式 C21H22N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide

参考文献

1. Bärfacker L, et al. ChemMedChem. 2012 Aug;7(8):1385-403.

2. Kolkhof P, et al. J Cardiovasc Pharmacol. 2014 Jul;64(1):69-78.

3. Filippatos G, et al. Eur Heart J. 2016 Jul 14;37(27):2105-14.

4. Amazit L, et al. J Biol Chem. 2015 Sep 4;290(36):21876-89.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: