Filibuvir | HCV NS5B inhibitor | Probechem Biochemicals

Chemical Structure : Filibuvir

CAS No.: 877130-28-4

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Filibuvir (PF-00868554, PF-868554)

货号: PC-61888Not For Human Use, Lab Use Only.

Filibuvir (PF-00868554, PF-868554) is a nonnucleoside, potent and selective, orally available HCV NS5B inhibitor with IC50 of 19 nM, EC50 of 75 nM (genotype 1b-Con1 replicon).

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10 mg	￥4580	In stock
25 mg	￥7580	In stock
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生物&药学活性

Filibuvir (PF-00868554, PF-868554) is a nonnucleoside, potent and selective, orally available HCV NS5B inhibitor with IC50 of 19 nM, EC50 of 75 nM (genotype 1b-Con1 replicon).
Filibuvir has potent in vitro antiviral activity against a majority (95.8%) of genotype 1a and 1b replicons with an overall mean EC50 of 59 nM, without cytotoxic effect in several human cell lines (CC50>320 uM).
Filibuvir exhibits good pharmacokinetic properties in preclinical animal species.

物理化学性质&存储条件

分子量	503.636
分子式	C29H37N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-Cyclopentyl-6-[2-(2,6-diethylpyridin-4-yl)ethyl]-3-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-5,6-dihydro-2H-pyran-2-one

参考文献

1. Li H, et al. J Med Chem. 2009 Mar 12;52(5):1255-8.

2. Shi ST, et al. Antimicrob Agents Chemother. 2009 Jun;53(6):2544-52.

3. Wagner F, et al. Hepatology. 2011 Jul;54(1):50-9. doi: 10.1002/hep.24342.

Filibuvir (PF-00868554, PF-868554)

生物&药学活性

物理化学性质&存储条件

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Filibuvir (PF-00868554, PF-868554)

生物&药学活性

物理化学性质&存储条件

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