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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-Filaminast
Filaminast

Chemical Structure : Filaminast

CAS No.: 141184-34-1

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Filaminast (WAY-PDA-641;PDA-641;WAY-123641)

货号: PC-63092Not For Human Use, Lab Use Only.

Filaminast (WAY-PDA-641, PDA-641, WAY-123641) is a potent and selective PDE4 inhibitor with IC50 of 420 nM, displays 36-fold selectivity over PDE3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Filaminast (WAY-PDA-641, PDA-641, WAY-123641) is a potent and selective PDE4 inhibitor with IC50 of 420 nM, displays 36-fold selectivity over PDE3.
Filaminast significantly potentiates the relaxant effects of albuterol, reverses tracheal contractions induced by prostaglandin F2 alpha, leukotriene D4 or histamine in a biphasic manner.

物理化学性质&存储条件

分子量 292.335
分子式 C15H20N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3-(Cyclopentyloxy)-4-methoxyphenyl)ethanone-(E)-O-(aminocarbonyl)oxime

参考文献

1. Heaslip RJ, et al. J Pharmacol Exp Ther. 1994 Feb;268(2):888-96.

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