Ficonalkib (SY-3505) | ALK inhibitor | Probechem Biochemicals

Chemical Structure : Ficonalkib

CAS No.: 2233574-95-1

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Ficonalkib (SY-3505, SY3505)

货号: PC-20033Not For Human Use, Lab Use Only.

Ficonalkib (SY-3505) is a potent, selective, 3rd-generation anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 1.3 nM and 1.5 nM for WT ALK, and F1174L mutant.

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1 mg	￥2480	In stock
5 mg	￥5980	In stock
10 mg	￥8980	In stock
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100 mg		Get quote

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生物&药学活性

Ficonalkib (SY-3505) is a potent, selective, 3rd-generation anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 1.3 nM and 1.5 nM for WT ALK, and F1174L mutant.
Ficonalkib (SY-3505) exhibits potent inhibition against both wild-type ALK and a diverse spectrum of mutants resistant to 1st- and 2nd-gen ALK TKI, including L1196M, G1202R, F1174L, G1269S, and R1275Q (IC50s=0.8-2.7 nM).
Ficonalkib (SY-3505) exhibits high kinase selectivity and has very weak inhibition on tropomyosin receptor kinase (TRK) family members (TRKA-C).

物理化学性质&存储条件

分子量	565.74
分子式	C29H39N7O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)-N4-(2-(isopropylsulfonyl)phenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

参考文献

1. Patent WO2018127184 A1.
2. Yuankai Shi, et al. J Thorac Oncol. 2024 Jun;19(6):898-911.

Ficonalkib (SY-3505, SY3505)

生物&药学活性

物理化学性质&存储条件

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Ficonalkib (SY-3505, SY3505)

生物&药学活性

物理化学性质&存储条件

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