Fibrostat

Chemical Structure : Fibrostat

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货号: PC-28757Not For Human Use, Lab Use Only.

Fibrostat is a potent, preferential HDAC6 inhibitor with IC50 of 63 nM (hHDAC6), displays 10-fold selectivity over hHDAC11, and >20-fold over hHDAC1/3/5/8/10.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

Fibrostat is a potent, preferential HDAC6 inhibitor with IC50 of 63 nM (hHDAC6), displays 10-fold selectivity over hHDAC11, and >20-fold over hHDAC1/3/5/8/10.
Fibrostat efficiently inhibits HDAC6, inducing marked acetylation of α-tubulin.
Fibrostat is able to negatively modulate the expression of fibrotic markers, fibronectin and collagen 1, in fibroblasts derived from bronchoalveolar lavages of IPF patients.
Fibrostat reduces the expression of fibronectin and negatively affected the expression of collagen 1 and vimentin in ex vivo IPF human model.

物理化学性质&存储条件

分子量	484.60
分子式	C29H32N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-benzyl-N-(4-(hydroxycarbamoyl)benzyl)-1,4-dihydro-2H-spiro[isoquinoline-3,4'-piperidine]-1'-carboxamide

参考文献

1. Fontana A, et al. ACS Pharmacol Transl Sci. 2024 Nov 12;8(2):380-393.

Fibrostat

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物理化学性质&存储条件

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Fibrostat

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物理化学性质&存储条件

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