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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Farnesoid X Receptor (FXR)-Fexaramine
Fexaramine

Chemical Structure : Fexaramine

CAS No.: 574013-66-4

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Fexaramine

货号: PC-42734Not For Human Use, Lab Use Only.

Fexaramine is a potent, specific FXR agonist with EC50 of 25 nM, more efficacious ligand for FXR than GW4064.

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25 mg ￥1380 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Fexaramine is a potent, specific FXR agonist with EC50 of 25 nM, more efficacious ligand for FXR than GW4064.
Fexaramine shows no transcriptional activity against hRXRα, hPPARα/γ/δ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, and hVDR.
Fexaramine strongly induces target genes SHP, PLTP BSEP, and MRP-2 in the HEPG2 liver cell system.
Fexaramine robustly induces FGF15, leading to alterations in BA composition.

物理化学性质&存储条件

分子量 496.6398
分子式 C32H36N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Propenoic acid, 3-[3-[(cyclohexylcarbonyl)[[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-, methyl ester

参考文献

1. Downes M, et al. Mol Cell. 2003 Apr;11(4):1079-92.

2. Fang S, et al. Nat Med. 2015 Feb;21(2):159-65.

3. Cho SW, et al. J Bone Miner Res. 2013 Oct;28(10):2109-21.

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