Fexaramine-3 | FXR agonist | Probechem Biochemicals

Chemical Structure : Fexaramine-3

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Fexaramine-3 (Fex-3, Fex3)

货号: PC-26701Not For Human Use, Lab Use Only.

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生物&药学活性

Fexaramine-3 (Fex-3, Fex3) is a potent, selective intestinal-restricted FXR agonist. significantly promotes the mRNA expression of BSEP and SHP and suppresses CYP7A1, all of which are the target genes of FXR.
Fexaramine-3 (Fex-3) targeted on FXR in ileum and has better selectivity than fexaramine.
Fexaramine-3 (Fex-3) effectively alleviated cholestatic liver injury by activating the intestinal FXR-fibroblast growth factor 15 (FGF15) signaling pathway, subsequently suppressed hepatic cholesterol 7α-hydroxylase (CYP7A1) expression.
Fexaramine-3 (Fex-3) alleviates cholestatic liver injury via FGF15-CYP7A1 axis in mouse models.

物理化学性质&存储条件

分子量	569.71
分子式	C37H35N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)-6-(methylamino)-2-naphthamido)phenyl)acrylate

参考文献

1. Wang H, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3386-3390.

Fexaramine-3 (Fex-3, Fex3)

生物&药学活性

物理化学性质&存储条件

参考文献

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Fexaramine-3 (Fex-3, Fex3)

生物&药学活性

物理化学性质&存储条件

参考文献

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