Fevipiprant | CRTH2 inhibitor | Probechem Biochemicals

Chemical Structure : Fevipiprant

CAS No.: 872365-14-5

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Fevipiprant (NVP-QAW039, QAW039)

货号: PC-45075Not For Human Use, Lab Use Only.

Fevipiprant (NVP-QAW039, QAW-039) is a potent, selective, slowly dissociating CRTh2 antagonist with Kd of 1.14 nM.

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生物&药学活性

Fevipiprant (NVP-QAW039, QAW-039) is a potent, selective, slowly dissociating CRTh2 antagonist with Kd of 1.14 nM.
NVP-QAW039 shows a half-life of 14.4 minutes, >7-fold slower than AZD-1981.
NVP-QAW039 inhibits PGD2-stimulated human eosinophil shape change, retains its potency in the whole-blood shape-change assay relative to the isolated shape change assays.
NVP-QAW039 also is a potent inhibitor of PGD2-induced cytokine release in human Th2 cells.

物理化学性质&存储条件

分子量	426.4095
分子式	C19H17F3N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, 2-methyl-1-[[4-(methylsulfonyl)-2-(trifluoromethyl)phenyl]methyl]-

参考文献

1. Sykes DA, et al. Mol Pharmacol. 2016 May;89(5):593-605.

2. Sandham DA, et al. ACS Med Chem Lett. 2017 Apr 25;8(5):582-586.

3. Bateman ED, et al. Eur Respir J. 2017 Aug 24;50(2). pii: 1700670.

Fevipiprant (NVP-QAW039, QAW039)

生物&药学活性

物理化学性质&存储条件

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Fevipiprant (NVP-QAW039, QAW039)

生物&药学活性

物理化学性质&存储条件

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