Fenebrutinib (RG7845, GDC-0853) | BTK inhibitor | Probechem Biochemicals

Chemical Structure : Fenebrutinib

CAS No.: 1434048-34-6

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Fenebrutinib (RG7845, GDC-0853, GDC0853)

货号: PC-45739Not For Human Use, Lab Use Only.

Fenebrutinib (RG-7845, GDC-0853) is an orally bioavailable, selective, non-covalent and reversible BTK inhibitor with IC50 of 2-9 nM.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Fenebrutinib (RG7845, GDC-0853) is an orally bioavailable, selective, non-covalent and reversible BTK inhibitor with IC50 of 2-9 nM.
Fenebrutinib (RG7845, GDC-0853) has demonstrated efficacy in pre-clinical autoimmune disease models and is being developed for the treatment of rheumatoid arthritis and lupus, with future development for other autoimmune indications.

物理化学性质&存储条件

分子量	664.7964
分子式	C37H44N8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 23 mg/mL
Chemical Name/SMILES	2H-Cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, 2-[1,6-dihydro-3'-(hydroxymethyl)-1-methyl-5-[[5-[(2S)-2-methyl-4-(3-oxetanyl)-1-piperazinyl]-2-pyridinyl]amino]-6-oxo[3,4'-bipyridin]-2'-yl]-3,4,7,8-tetrahydro-7,7-dimethyl-

参考文献

1. Erickson RI, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):226-238.

2. Katsumoto, T. 2016 ACR/ARHP Annual Meeting (2016).

Fenebrutinib (RG7845, GDC-0853, GDC0853)

生物&药学活性

物理化学性质&存储条件

参考文献

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Fenebrutinib (RG7845, GDC-0853, GDC0853)

生物&药学活性

物理化学性质&存储条件

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