Feeblin | IRF5 inhibitor | Probechem Biochemicals

Chemical Structure : Feeblin

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Feeblin (SLC15A4 inhibitor C5)

货号: PC-21265Not For Human Use, Lab Use Only.

Feeblin (SLC15A4 inhibitor C5) is a small molecule inhibitor of the proinflammatory TLR7/8/9-IRF5 pathway (IC50=1.6 uM) by disrupting the SLC15A4-TASL adapter module, Feeblin is an IRF5 pathway-specific inhibitor.

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生物&药学活性

Feeblin (SLC15A4 inhibitor C5) is a small molecule inhibitor of the proinflammatory TLR7/8/9-IRF5 pathway (IC50=1.6 uM) by disrupting the SLC15A4-TASL adapter module, Feeblin is an IRF5 pathway-specific inhibitor.
Feeblin (SLC15A4 inhibitor C5) displays specific inhibition of IRF5, shows no or little activity on STING, NOD1/2 or RIG-like helicase pathways.
Feeblin (SLC15A4 inhibitor C5) significantly reduces IRF5 nuclear translocation, without affecting the activation of NF-κB p65.
Feeblin (SLC15A4 inhibitor C5) locks SLC15A4 in a TASL binding-incompetent lysosomal outward-open conformation.

物理化学性质&存储条件

分子量	431.58
分子式	C27H33N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-ethoxyphenyl)-N-(3-(2-methylpiperidin-1-yl)propyl)quinoline-4-carboxamide

参考文献

1. Andras Boeszoermenyi, et al. Nat Commun. 2023 Oct 20;14(1):6626.

Feeblin (SLC15A4 inhibitor C5)

生物&药学活性

物理化学性质&存储条件

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Feeblin (SLC15A4 inhibitor C5)

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物理化学性质&存储条件

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