Febuxostat (TEI-6720) | Xanthine oxidase inhibitor | Probechem Biochemicals

Chemical Structure : Febuxostat

CAS No.: 144060-53-7

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Febuxostat (TEI-6720, TEI 6720)

货号: PC-20360Not For Human Use, Lab Use Only.

Febuxostat (TEI-6720) is a potent xanthine oxidase/xanthine dehydrogenase (XO) inhibitor, inhibit bovine milk XO, and mouse liver and rat liver XO with IC50 of 1.4, 1.8 and 2.2 nM, respectively.

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50 mg	￥980	In stock
100 mg	￥1480	In stock
500 mg	￥2980	In stock
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生物&药学活性

Febuxostat (TEI-6720) is a potent xanthine oxidase/xanthine dehydrogenase (XO) inhibitor, inhibit bovine milk XO, and mouse liver and rat liver XO with IC50 of 1.4, 1.8 and 2.2 nM, respectively.
TEI-6720 exhibited mixed-type inhibition and the Ki value was 0.7 nM on bovine milk xanthine oxidase.
TEI-6720 displayed prolonged urate-lowering activity in normal mice and rats.
TEI-6720 reduced the combined molarity of uric acid and allantoin in rats with ED50 of 2.1 mg/kg p.o.

物理化学性质&存储条件

分子量	316.38
分子式	C16H16N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazole-carboxylic acid

参考文献

1. Osada Y, et al. Eur J Pharmacol. 1993 Sep 14;241(2-3):183-8.

2. Komoriya K, et al. Eur J Pharmacol. 1993 Dec 21;250(3):455-60.

Febuxostat (TEI-6720, TEI 6720)

生物&药学活性

物理化学性质&存储条件

参考文献

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Febuxostat (TEI-6720, TEI 6720)

生物&药学活性

物理化学性质&存储条件

参考文献

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