Fasudil (AT-877, HA-1077) | ROCK inhibitor | Probechem Biochemicals

Chemical Structure : Fasudil

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Fasudil (AT-877, HA-1077, AT877; HA1077)

货号: PC-42541Not For Human Use, Lab Use Only.

Fasudil (AT-877, HA-1077) is a potent and selective inhibitor of Rho kinase (ROCK) with Ki of 0.33 uM (ROCK1).

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生物&药学活性

Fasudil (AT-877, HA-1077) is a potent and selective inhibitor of Rho kinase (ROCK) with Ki of 0.33 uM (ROCK1).
Fasudil (AT-877, HA-1077) displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively.
Fasudil (AT-877, HA-1077) exhibits vasodilator actions by inhibition of 5-hydroxytryptamine, noradrenaline, histamine, angiotensin, and dopamine induced spiral strips contraction.

物理化学性质&存储条件

分子量	291.3687
分子式	C14H17N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-

参考文献

1. Uehata M, et al. Nature. 1997 Oct 30;389(6654):990-4.

2. Asano T, et al. J Pharmacol Exp Ther. 1987 Jun;241(3):1033-40.

3. Asano T, et al. Br J Pharmacol. 1989 Dec;98(4):1091-100.

Fasudil (AT-877, HA-1077, AT877; HA1077)

生物&药学活性

物理化学性质&存储条件

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Fasudil (AT-877, HA-1077, AT877; HA1077)

生物&药学活性

物理化学性质&存储条件

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