Fasnall benzenesulfonate

Chemical Structure : Fasnall benzenesulfonate

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货号: PC-20377Not For Human Use, Lab Use Only.

Fasnall benzenesulfonate is a potent, selective fatty acid synthase (FASN) inhibitor with IC50 of 3.71 uM for purified human FASN isolated from the BT474 cell line.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
200 mg		Get quote

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生物&药学活性

Fasnall benzenesulfonate is a potent, selective fatty acid synthase (FASN) inhibitor with IC50 of 3.71 uM for purified human FASN isolated from the BT474 cell line.
Fasnall potently blocked both acetate and glucose incorporation into total lipids, with IC50 values of 147 and 213 nM, respectively, in HepG2 cells.
Fasnall inhibits the incorporation of tritiated acetat in BT474 cells with IC50 of 5.84 uM.
Fasnall does not inhibit ACC (acetyl-CoA carboxylase), Hsp90, Hsp70, TRAP-1, DAP kinase 3, IRAK 2, AMPK α and γ subunits, NEK9, dengue nonstructural protein 5, malarial kinase PfPK9, and HSF-1.
Fasnall inhibited the proliferation of aggressive breast cancer cell lines, with profound changes in cellular lipid profiles, sharply increasing ceramides, diacylglycerols, and unsaturated fatty acids.
Fasnall (5-15 mg/kg) showed potent anti-tumor activity in the MMTV-Neu model of HER2+ breast cancer.

物理化学性质&存储条件

分子量	496.64
分子式	C25H28N4O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-benzylpyrrolidin-3-yl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine benzenesulfonate

参考文献

1. Alwarawrah Y, et al. Cell Chem Biol. 2016 Jun 23;23(6):678-88.

2. Gifford GK, et al. Leuk Lymphoma. 2020 Aug;61(8):1810-1822.