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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Fatty Acid Synthase-Fasnall
Fasnall

Chemical Structure : Fasnall

CAS No.: 929978-58-5

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Fasnall

货号: PC-20378Not For Human Use, Lab Use Only.

Fasnall is a potent, selective fatty acid synthase (FASN) inhibitor with IC50 of 3.71 uM for purified human FASN isolated from the BT474 cell line.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3680 In stock
50 mg ￥5580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Fasnall is a potent, selective fatty acid synthase (FASN) inhibitor with IC50 of 3.71 uM for purified human FASN isolated from the BT474 cell line.
Fasnall potently blocked both acetate and glucose incorporation into total lipids, with IC50 values of 147 and 213 nM, respectively, in HepG2 cells.
Fasnall inhibits the incorporation of tritiated acetat in BT474 cells with IC50 of 5.84 uM.
Fasnall does not inhibit ACC (acetyl-CoA carboxylase), Hsp90, Hsp70, TRAP-1, DAP kinase 3, IRAK 2, AMPK α and γ subunits, NEK9, dengue nonstructural protein 5, malarial kinase PfPK9, and HSF-1.
Fasnall inhibited the proliferation of aggressive breast cancer cell lines, with profound changes in cellular lipid profiles, sharply increasing ceramides, diacylglycerols, and unsaturated fatty acids.
Fasnall (5-15 mg/kg) showed potent anti-tumor activity in the MMTV-Neu model of HER2+ breast cancer.

物理化学性质&存储条件

分子量 338.47
分子式 C19H22N4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]-thieno[2,3-d]pyrimidin-4-amine

参考文献

1. Alwarawrah Y, et al. Cell Chem Biol. 2016 Jun 23;23(6):678-88.

2. Gifford GK, et al. Leuk Lymphoma. 2020 Aug;61(8):1810-1822.

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