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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Glucose Transporter (GLUT)-Fasentin
Fasentin

Chemical Structure : Fasentin

CAS No.: 392721-37-8

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Fasentin

货号: PC-62895Not For Human Use, Lab Use Only.

Fasentin is a novel inhibitor of glucose uptake (GLUT) that sensitizes cancer cells to FAS-induced cell death, preferentially inhibits GLUT4 (IC50=68 uM) over GLUT1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Fasentin is a novel inhibitor of glucose uptake (GLUT) that sensitizes cancer cells to FAS-induced cell death, preferentially inhibits GLUT4 (IC50=68 uM) over GLUT1.
Fasentin sensitizes cancer cells to the death ligands FAS and TNF apoptosis-inducing ligand, and induces G1 cell cycle arrest.

物理化学性质&存储条件

分子量 279.643
分子式 C11H9ClF3NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

参考文献

1. Wood TE, et al. Mol Cancer Ther. 2008 Nov;7(11):3546-55.

2. Schimmer AD, et al. Cancer Res. 2006 Feb 15;66(4):2367-75.

3. Granchi C, et al. Medchemcomm. 2016 Sep 1;7(9):1716-1729.

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