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Fadrozole hydrochloride

Chemical Structure : Fadrozole hydrochloride

CAS No.: 102676-31-3

Fadrozole hydrochloride (CGS 16949A, FAD286, FAD 286)

货号: PC-60699Not For Human Use, Lab Use Only.

Fadrozole (FAD286) hydrochloride is a potent and selective, orally bioavailable aromatase inhibitor with IC50 of 1.7 nM, 180 times more potent than aminoglutethimide.

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10 mg ¥780 In stock
25 mg ¥1280 In stock
50 mg ¥2180 In stock
100 mg ¥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Fadrozole (FAD286) hydrochloride is a potent and selective, orally bioavailable aromatase inhibitor with IC50 of 1.7 nM, 180 times more potent than aminoglutethimide.
Fadrozole (FAD286) lowers ovarian estrogen synthesis by gonadotropin-primed, androstenedione treated mice, suppresses hormone-dependent and -independent tumors in vivo.

物理化学性质&存储条件

分子量 259.737
分子式 C14H14ClN3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride

参考文献

1. Steele RE, et al. Steroids. 1987 Jul-Sep;50(1-3):147-61.

2. Schieweck K, et al. Cancer Res. 1988 Feb 15;48(4):834-8.

3. Juniewicz PE, et al. J Urol. 1988 Apr;139(4):827-31.

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