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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Complement System-Factor D inhibitor 7
Factor D inhibitor 7

Chemical Structure : Factor D inhibitor 7

CAS No.: 1386455-76-0

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Factor D inhibitor 7

货号: PC-62225Not For Human Use, Lab Use Only.

Factor D inhibitor 7 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 50 nM.

规格 价格 库存 数量
5 mg ￥3280 In stock
10 mg ￥5280 In stock
25 mg ￥8980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Factor D inhibitor 7 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 50 nM.
Factor D inhibitor 7 is highly selective for human FD, showing no inhibition of factor B.
Factor D inhibitor 7 efficiently block alternative pathway activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes.
Factor D inhibitor 7 inhibits lipopolysaccharide-induced AP activation in FD-humanized mice.

物理化学性质&存储条件

分子量 483.326
分子式 C21H19BrN6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2-((1R,3S,5R)-3-((6-bromopyridin-2-yl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1H-indazole-3-carboxamide

参考文献

1. Maibaum J, et al. Nat Chem Biol. 2016 Dec;12(12):1105-1110.

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