Fabimycin

Chemical Structure : Fabimycin

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货号: PC-49315Not For Human Use, Lab Use Only.

Fabimycin is a potent, specific inhibitor of the enoyl-acyl carrier protein reductase enzyme FabI, exhibits impressive activity against >200 clinical isolates of Escherichia coli, Klebsiella pneumoniae (MIC, 1 ug/mL), and Acinetobacter baumannii, and does not kill commensal bacteria.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Fabimycin is a potent, specific inhibitor of the enoyl-acyl carrier protein reductase enzyme FabI, exhibits impressive activity against >200 clinical isolates of Escherichia coli, Klebsiella pneumoniae (MIC, 1 ug/mL), and Acinetobacter baumannii, and does not kill commensal bacteria.
Fabimycin potently inhibits A. baumannii and E. coli FabI with IC50 of <10 nM in enzyme assays.
Fabimycin inhibited 90% of a panel of 100 K. pneumoniae clinical isolates at 4 μg/mL, relative to 32 μg/mL for levofloxacin.
Fabimycin demonstrates in vivo efficacy in murine urinary tract infection (UTI).

物理化学性质&存储条件

分子量	440.928
分子式	C23H25ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-3-(7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)acrylamide hydrochloride

参考文献

1. Erica N Parker, et al. ACS Cent Sci. 2022 Aug 24;8(8):1145-1158.

Fabimycin

生物&药学活性

物理化学性质&存储条件

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Fabimycin

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