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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Frizzled-FZD7 antagonist F7H
FZD7 antagonist F7H

Chemical Structure : FZD7 antagonist F7H

CAS No.: 897109-93-2

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FZD7 antagonist F7H

货号: PC-21133Not For Human Use, Lab Use Only.

FZD7 antagonist F7H is a small molecule antagonist of the transmembrane domain of frizzled receptor FZD7 (FZD7-TMD, SPR KD=0.16 uM), blocks Wnt3A-mediated stabilization of β-catenin in HEK293T cells with IC50 of 1.25 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

FZD7 antagonist F7H is a small molecule antagonist of the transmembrane domain of frizzled receptor FZD7 (FZD7-TMD, SPR KD=0.16 uM), blocks Wnt3A-mediated stabilization of β-catenin in HEK293T cells with IC50 of 1.25 uM.
FZD7 antagonist F7H does not bind the SMO protein indicative of the potential selectivity.

物理化学性质&存储条件

分子量 463.55
分子式 C24H18FN3O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Fluoro-N-(4-((2-oxo-2-((4-phenylthiazol-2-yl)amino)ethyl)thio)phenyl)benzamide

参考文献

1. Li C, et al. J Med Chem. 2023 Sep 5. doi: 10.1021/acs.jmedchem.2c01795.

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