FX1 | BCL6 inhibitor | Probechem Biochemicals

Chemical Structure : FX1

CAS No.: 1426138-42-2

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FX1 (BCL6 inhibitor FX1)

货号: PC-60927Not For Human Use, Lab Use Only.

FX1 (BCL6 inhibitor FX1) is a potent, specific BCL6 BTB domain inhibitor with Kd of 7 uM, binds with a greater affinity than the natural BCL6 ligand SMRT (Kd=30 uM).

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
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生物&药学活性

FX1 (BCL6 inhibitor FX1) is a potent, specific BCL6 BTB domain inhibitor with Kd of 7 uM, binds with a greater affinity than the natural BCL6 ligand SMRT (Kd=30 uM).
FX1 exhibits 10-fold greater inhibitory activity against the BCL6 BTB domain in reporter assays with IC50 of 35 uM, displays good selectivity against a panel of 50 different kinases.
FX1 disrupts formation of the BCL6 repression complex, reactivates BCL6 target genes, suppresses ABC-DLBCL cells in vitro and in vivo, as well as primary human ABC-DLBCL specimens ex vivo.

物理化学性质&存储条件

分子量	368.806
分子式	C14H9ClN2O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mg/mL in DMSO
Chemical Name/SMILES	(Z)-3-(5-(5-chloro-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid

参考文献

1. Cardenas MG, et al. J Clin Invest. 2016 Sep 1;126(9):3351-62.

2. Deb D, et al. Cancer Res. 2017 Jun 1;77(11):3070-3081.

FX1 (BCL6 inhibitor FX1)

生物&药学活性

物理化学性质&存储条件

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FX1 (BCL6 inhibitor FX1)

生物&药学活性

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