FX-11 |CAS:213971-34-7 Probechem Biochemicals

Chemical Structure : FX-11

CAS No.: 213971-34-7

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FX-11 (LDHA inhibitor FX11)

货号: PC-62049Not For Human Use, Lab Use Only.

FX-11 (LDHA inhibitor FX11) is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehydrogenase A (LDHA) with Ki of 50 nM (LDHA subunit M), less potent for LDHB or pLDH.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FX-11 (LDHA inhibitor FX11) is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehydrogenase A (LDHA) with Ki of 50 nM (LDHA subunit M), less potent for LDHB or pLDH.
FX-11 reduces ATP levels and induces oxygen consumption, ROS production and cell death.
FX-11 inhibits the progression of sizable human lymphoma and pancreatic cancer xenografts, and induces lymphoma regression in combination with FK886.

物理化学性质&存储条件

分子量	350.414
分子式	C22H22O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 250 mg/mL
Chemical Name/SMILES	2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid

参考文献

1. Le A, et al. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42.

2. Deck LM, et al. J Med Chem. 1998 Sep 24;41(20):3879-87.

3. Yu Y, et al. Biochem Pharmacol. 2001 Jul 1;62(1):81-9.

FX-11 (LDHA inhibitor FX11)

生物&药学活性

物理化学性质&存储条件

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FX-11 (LDHA inhibitor FX11)

生物&药学活性

物理化学性质&存储条件

参考文献

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