FTX-6746 | PPARγ inhibitor | Probechem Biochemicals

Chemical Structure : FTX-6746

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FTX-6746 (FTX6746, FTX 6746)

货号: PC-20679Not For Human Use, Lab Use Only.

FTX-6746 (FTX6746) is a potent, highly selective and orally active proliferator-activated receptor gamma (PPARG, PPARγ) inhibitor with cellular IC50 of 5 nM, >100-fold selectivity over PPARD and PPARA.

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生物&药学活性

FTX-6746 (FTX6746) is a potent, highly selective and orally active proliferator-activated receptor gamma (PPARG, PPARγ) inhibitor with cellular IC50 of 5 nM, >100-fold selectivity over PPARD and PPARA.
FTX-6746 exhibits potent in vitro growth inhibition preferentially in cell lines with activated PPARG signaling.
FTX-6746 (3, 10, 30 and 60 mg/kg, twice daily, oral) demonstrated tumor growth inhibition or regression in UMUC9 xenograft tumors.

物理化学性质&存储条件

分子量	316.69
分子式	C16H7ClF2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-3-(5,7-difluoro-4-oxo-1,4-dihydroquinolin-2-yl)benzonitrile

参考文献

1. J. Mertz, et al. European Journal of Cancer. 6 OCTOBER 2022 12:00–20:00: POSTER SESSION: NEW DRUGS

2. Patent WO2022187203 A1.

FTX-6746 (FTX6746, FTX 6746)

生物&药学活性

物理化学性质&存储条件

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FTX-6746 (FTX6746, FTX 6746)

生物&药学活性

物理化学性质&存储条件

参考文献

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