FTO-43 | FTO inhibitor | Probechem Biochemicals

Chemical Structure : FTO-43

CAS No.: 2640366-38-5

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FTO-43 (FTO-43 N)

货号: PC-49236Not For Human Use, Lab Use Only.

FTO-43 (FTO-43 N) is a potent, selective inhibitor of the m6A demethylase fat mass- and obesity-associated protein (FTO) with IC50 of 1.0 uM, no significant acitivity against the homologous m6A RNA demethylase ALKBH5 (IC50>40 uM).

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

FTO-43 (FTO-43 N) is a potent, selective inhibitor of the m6A demethylase fat mass- and obesity-associated protein (FTO) with IC50 of 1.0 uM, no significant acitivity against the homologous m6A RNA demethylase ALKBH5 (IC50>40 uM).
FTO-43 N shows potent antiproliferative effects in glioblastoma, acute myeloid leukemia, and gastric cancer models (SNU-16 cells, IC50=17.7 uM).
FTO-43 N increases m6A and m6Am levels in gastric cancer cells consistent with FTO knockdown, downregulates Wnt/PI3K-Akt signaling in AGS gastric cancer cells.

物理化学性质&存储条件

分子量	346.855
分子式	C19H23ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-(2-Chlorophenyl)furan-2-yl)-N-((3-(pyrrolidin-1-yl)oxetan-3-yl)methyl)methanamine

参考文献

1. Sarah Huff, et al. J Med Chem. 2022 Aug 8. doi: 10.1021/acs.jmedchem.1c02075.

FTO-43 (FTO-43 N)

生物&药学活性

物理化学性质&存储条件

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FTO-43 (FTO-43 N)

生物&药学活性

物理化学性质&存储条件

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