FTBMT | GPR52 agonist | Probechem Biochemicals

Chemical Structure : FTBMT

CAS No.: 1358575-02-6

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FTBMT (TP024, TP-024)

货号: PC-35386Not For Human Use, Lab Use Only.

FTBMT (TP024) is a novel selective GPR52 agonist, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively.

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生物&药学活性

FTBMT (TP024) is a novel selective GPR52 agonist, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively.
FTBMT does not show significant inhibition or stimulation in a panel of 98 other targets, including receptors, ion channels, and enzymes.
FTBMT elevates the levels of cAMP (pEC50=6.82) and phosho-CREB, which increased the expression of downstream CREB target genes, c-fos and Egr-2.
FTBMT inhibits MK-801-induced hyperactivity, shows antipsychotic and recognitive properties without causing catalepsy in rodents.

物理化学性质&存储条件

分子量	392.35
分子式	C19H16F4N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(3-Fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide

参考文献

1. Nishiyama K, et al. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264.

FTBMT (TP024, TP-024)

生物&药学活性

物理化学性质&存储条件

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FTBMT (TP024, TP-024)

生物&药学活性

物理化学性质&存储条件

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