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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-FT385
FT385

Chemical Structure : FT385

CAS No.:

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FT385 (FT3967385)

货号: PC-72253Not For Human Use, Lab Use Only.

FT385 (FT3967385) is a potent, selective USP30 inhibitor with biochemical IC50 of 1.5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FT385 (FT3967385) is a potent, selective USP30 inhibitor with biochemical IC50 of 1.5 nM.
FT385 (FT3967385) displays high selectivity against a broad panel of USP enzymes, with one exception of plasma membrane-associated USP6.
FT385 engages USP30 in cells at low nanomolar concentrations.
Inhibition of USP30 via FT385 phenocopies USP30 KO in enhancing basal mitophagy and promoting ubiquitylation of TOM20 upon depolarisation, enhances phospho-Ser65 ubiquitin (pUb) levels on mitochondria of SHSY5Y cells.

物理化学性质&存储条件

分子量 373.416
分子式 C21H19N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-N-(1-cyanopyrrolidin-3-yl)-3-(2-phenoxyphenyl)-1H-pyrazole-5-carboxamide

参考文献

1. Emma V Rusilowicz-Jones, et al. Life Sci Alliance. 2020 Jul 7;3(8):e202000768.

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