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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-FT206
FT206

Chemical Structure : FT206

CAS No.: 2278274-34-1

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FT206 (FT-206, FT3951206, CRT0511973)

货号: PC-38173Not For Human Use, Lab Use Only.

FT206 (FT-206, FT3951206, CRT0511973) is a potent, selectivel inhibitor of USP28 with a remarkable USP28/25 selectivity.

规格 价格 库存 数量
5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FT206 (FT-206, FT3951206, CRT0511973) is a potent, selectivel inhibitor of USP28 with a remarkable USP28/25 selectivity.
FT206 interferes with USP28/25 probe labelling (USP-ABP versus USP) in LSCC H520 cell extracts with EC50 of 0.3-1 uM.
USP28 inhibition causes apoptotic cell death of LSCC tumour cells.
FT206 also resulted in reduced Δp63, c-JUN, and c-MYC protein levels, causes dramatic regression of human LSCC xenograft tumours in vivo.

物理化学性质&存储条件

分子量 447.601
分子式 C25H29N5OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-[(2S)-6-(3,8-diazabicyclo[3.2.1]oct-3-yl)-1,2,3,4-tetrahydro-2-naphthalenyl]-6-methyl-

参考文献

1. E Josue Ruiz, et al. Elife. 2021 Oct 12;10:e71596.

2. Jonathan D Wrigley, et al. ACS Chem Biol. 2017 Dec 15;12(12):3113-3125.

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