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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Fatty Acid Synthase-FT113
FT113

Chemical Structure : FT113

CAS No.: 1630808-89-7

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FT113 (FT-113)

货号: PC-72348Not For Human Use, Lab Use Only.

FT113 (FT-113) is a potent inhibitor of fatty acid synthase (FASN) with IC50 of 213 nM (hFASN).

规格 价格 库存 数量
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
50 mg ￥7280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FT113 (FT-113) is a potent inhibitor of fatty acid synthase (FASN) with IC50 of 213 nM (hFASN).
FT113 showed anti-proliferative activity against prostate (PC3 cell line), breast (BT-474 cell line), and leukemia (MV-411 cell line, IC50=26 nM) cancer cells.
FT113 exhibited tumor growth inhibition of 32% and 50% by treatment with 25 and 50 mg/kg, respectively, increased malonyl-CoA levels in vivo.

物理化学性质&存储条件

分子量 409.417
分子式 C22H20FN3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(4-(6-Fluorobenzo[d]oxazol-2-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone

参考文献

1. Matthew W Martin, et al. Bioorg Med Chem Lett. 2019 Apr 15;29(8):1001-1006.

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