FT011 | Collagen synthesis inhibitor | Probechem Biochemicals

Chemical Structure : FT011

CAS No.: 1001288-58-9

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FT011 (FT-011, SHP-627)

货号: PC-42176Not For Human Use, Lab Use Only.

FT011 (SHP-627) is an anti-fibrotic agent that prevents TGF-beta-stimulated production of collagen in cultured renal mesangial cells (55-70% inhibition at 30 uM).

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10 mg	￥780	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg		Get quote

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生物&药学活性

FT011 (SHP-627) is an anti-fibrotic agent that prevents TGF-beta-stimulated production of collagen in cultured renal mesangial cells (55-70% inhibition at 30 uM).
FT011 inhibits both TGF-β1 and PDGF-BB induced collagen production as well as PDGF-BB-mediated mesangial proliferation, attenuates the decline in GFR, proteinuria and glomerulosclerosis in a robust model of non-diabetic kidney disease.
FT011 attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy.

物理化学性质&存储条件

分子量	351.3527
分子式	C20H17NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	Benzoic acid, 2-[[(2E)-3-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]-1-oxo-2-propen-1-yl]amino]-

参考文献

1. Zammit SC, et al. Bioorg Med Chem Lett. 2009 Dec 15;19(24):7003-6.

2. Zhang Y, et al. Eur J Heart Fail. 2012 May;14(5):549-62.

3. Gilbert RE, et al. PLoS One. 2012;7(10):e47160.

4. Deliyanti D, et al. PLoS One. 2015 Jul 29;10(7):e0134392.

FT011 (FT-011, SHP-627)

生物&药学活性

物理化学性质&存储条件

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FT011 (FT-011, SHP-627)

生物&药学活性

物理化学性质&存储条件

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