FT-671 | USP7 inhibitor | Probechem Biochemicals

Chemical Structure : FT-671

CAS No.: 1959551-26-8

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FT-671 (FT671, FT 671)

货号: PC-60088Not For Human Use, Lab Use Only.

FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).

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10 mg	￥7580	In stock
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生物&药学活性

FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).
FT-671 inhibits USP7 with IC50 values of 52 nM (USP7 CD) and 69 nM (USP7C-term), display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs).
FT-671 destabilizes USP7 substrates including MDM2, increases levels of p53, and results in the transcription of p53 target genes and induces tumour suppressor p21.
FT-671 blocks the proliferation of MM.1S cells (IC50=33 nM), suppresses tumour growth in mice; orally available.

物理化学性质&存储条件

分子量	533.488
分子式	C24H23F4N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-((1-(4,4-difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

参考文献

1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.

FT-671 (FT671, FT 671)

生物&药学活性

物理化学性质&存储条件

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FT-671 (FT671, FT 671)

生物&药学活性

物理化学性质&存储条件

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