FT-1101 |CAS: 1776060-36-6 Probechem Biochemicals

Chemical Structure : FT-1101

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FT-1101 (FT1101, FT 1101)

货号: PC-62284Not For Human Use, Lab Use Only.

FT-1101 is a potent pan-BET bromodomain inhibitor that displays equipotent inhibition for BRD2, BRD3, BRD4, and BRDT with Kd < 20 nM.

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生物&药学活性

FT-1101 is a potent pan-BET bromodomain inhibitor that displays equipotent inhibition for BRD2, BRD3, BRD4, and BRDT with Kd < 20 nM.
FT-1101 displays potent anti-proliferative activity across a broad panel of human leukemia, lymphoma, and multiple myeloma cell lines, with 66 out of 123 cell lines having IC50 < 500 nM (IC50=40 nM, MV-4-11 cells).
FT-1101 down-regulates MYC gene and protein expression.
FT-1101 significantly tumor growth in the MV-4-11 xenograft model; orally bioavtive.

物理化学性质&存储条件

分子量	434.58
分子式	C26H34N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[(2S)-5-(Cyclobutyloxy)-3,4-dihydro-2-methyl-6-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-1(2H)-quinolinyl]cyclopropylmethanone

参考文献

1. David S Millan, et al. Blood. 2015 126:1367.

FT-1101 (FT1101, FT 1101)

生物&药学活性

物理化学性质&存储条件

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FT-1101 (FT1101, FT 1101)

生物&药学活性

物理化学性质&存储条件

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