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首页-小分子抑制剂&激动剂-Others-Other Targets-FSC231
FSC231

Chemical Structure : FSC231

CAS No.: 1215849-96-9

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FSC231 (FSC-231, FSS 231)

货号: PC-62059Not For Human Use, Lab Use Only.

FSC231 (FSC-231) is the first, cell-permeable small-molecule inhibitor of PICK1 PDZ domain with Kd of 10.1 uM.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FSC231 (FSC-231) is the first, cell-permeable small-molecule inhibitor of PICK1 PDZ domain with Kd of 10.1 uM.
FSC231 inhibits the interaction between GluR2 and PICK1, accelerates recycling of pHluorin-tagged GluR2 in hippocampal neurons.
FSC231 blocks the expression of both long-term depression and long-term potentiation in rats and murine hippocampal neurons.

物理化学性质&存储条件

分子量 313.134
分子式 C13H10Cl2N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-ethyl 2-cyano-3(3,4-dichlorophenyl)acryloylcarbamate

参考文献

1. Thorsen TS, et al. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):413-8.

2. Qiu CY, et al. J Neuroinflammation. 2012 May 29;9:108.

3. Herbert LM, et al. Am J Physiol Cell Physiol. 2016 Mar 1;310(5):C390-400.

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