FS2921 | GluN1/GluN2A NMDAR PAM | Probechem Biochemicals

Chemical Structure : FS2921

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FS2921 (FS-2921)

货号: PC-22455Not For Human Use, Lab Use Only.

FS2921 is a potential, functionally selective GluN1/GluN2A positive allosteric modulator (PAM), selective versus GluN1/GluN2B and GluN1/GluN2D, increases NMDAR-mediated currents with EC50 of 8.8 uM.

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生物&药学活性

FS2921 is a potential, functionally selective GluN1/GluN2A NMDAR positive allosteric modulator (PAM), selective versus GluN1/GluN2B and GluN1/GluN2D, increases NMDAR-mediated currents with EC50 of 8.8 uM.
FS2921 exhibits a weak NAM effect for GluN1/GluN2C but does not show any influence on native AMPA receptors and GABA receptors.
FS2921 slightly increases NMDA potency from 23.9 ± 1.3 to 13.6 ± 1.1 μM, but has no influence on the maximum currents induced by saturated NMDA.
FS2921 moderately decreased the immobility time in the FST.
FS2921 moderately reversed the reduction in social interactions induced by CSDS and exhibited an equal antidepressant effect compared with that of fluoxetine.

物理化学性质&存储条件

分子量	388.27
分子式	C18H18BrN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-bromo-2-methylphenyl)-5-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)furan-2-carboxamide

参考文献

1. Zhongtang Li, et al. J Med Chem. 2021 May 13;64(9):5551-5576.

FS2921 (FS-2921)

生物&药学活性

物理化学性质&存储条件

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FS2921 (FS-2921)

生物&药学活性

物理化学性质&存储条件

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