FRS2 ligand 7

Chemical Structure : FRS2 ligand 7

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货号: PC-49580Not For Human Use, Lab Use Only.

FRS2 ligand 7 is a small molecule ligand of the PTB domain of FGFR proximal adaptor protein FRS2, prevents FRS2 activation and interrupts FGFR signaling, inhibits invasion and tumor growth.

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生物&药学活性

FRS2 ligand 7 is a small molecule ligand of the PTB domain of FGFR proximal adaptor protein FRS2, prevents FRS2 activation and interrupts FGFR signaling, inhibits invasion and tumor growth.
FRS2 ligand 7 inhibited basal and bFGF-induced phosphorylation of extracellular regulated kinase ERK (pT202/Y204) in DAOY, SW780, M059K, SKOV3, AGS, DMS114 and RT-112 cells.
FRS2 ligand 7 inhibited collagen I invasion in both bFGF-sensitive and bFGF-insensitive cell lines.
FRS2 ligand 7 acts on FRS2 and displays limited off-target activities.
FRS2 ligand 7 is comparable to that of the structurally and functionally unrelated FGFR inhibitor BGJ398.
FRS2 ligand 7 (200 mg/kg, once per day PO) blocked cancer growth in the SKOV03 model in vivo.

物理化学性质&存储条件

分子量	377.22
分子式	C18H14Cl2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-chloro-4-(4-chlorophenyl)-9-nitro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-6-ol

参考文献

1. Santhana Kumar K, et al. Cell Oncol (Dordr). 2022 Dec 10. doi: 10.1007/s13402-022-00753-x.

FRS2 ligand 7

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FRS2 ligand 7

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