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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-p21-activated Kinase (PAK)-FRAX597
FRAX597

Chemical Structure : FRAX597

CAS No.: 1286739-19-2

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FRAX597 (FRAX 597, FRAX-597)

货号: PC-44510Not For Human Use, Lab Use Only.

FRAX597 is a potent, selective ATP-competitive inhibitor of group I PAKs with IC50 of 8/13/19 nM for PAK1/2/3.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FRAX597 is a potent, selective ATP-competitive inhibitor of group I PAKs with IC50 of 8/13/19 nM for PAK1/2/3.
FRAX597 shows no effect on PAK4 (IC50>10 uM).
FRAX597 inhibits the proliferation of NF2-deficient schwannoma cells in culture.
FRAX597 displays potent anti-tumor activity in vivo, impairing schwannoma development in an orthotopic model of NF2.

物理化学性质&存储条件

分子量 558.0969
分子式 C29H28ClN7OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-

参考文献

1. Licciulli S, et al. J Biol Chem. 2013 Oct 4;288(40):29105-14.

2. Chow HY, et al. Cancer Res. 2012 Nov 15;72(22):5966-75.

3. Yeo D, et al. BMC Cancer. 2016 Jan 16;16:24.

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