FRAX1036 | PAK inhibitor | Probechem Biochemicals

Chemical Structure : FRAX1036

CAS No.: 1432908-05-8

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FRAX1036 (FRAX-1036, FRAX 1036)

货号: PC-45644Not For Human Use, Lab Use Only.

FRAX1036 is a potent and selective inhibitor of group I PAKs (PAK1, Ki=23.3 nM; PAK2, Ki=72.4 nM).

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

FRAX1036 is a potent and selective inhibitor of group I PAKs (PAK1, Ki=23.3 nM; PAK2, Ki=72.4 nM).
FRAX1036 displays weak affinity on PAK4 (Ki = 2.4 uM).
FRAX1036 inhibits phosphorylation of MEK1-S298 and CRAF-S338 at 2.5-5 uM in MDA-MB-175 cells.
FRAX1036 inhibits MPNST cell growth in vitro and dramatically decreases local and metastatic MPNST growth in animal models combined with PD0325901.

物理化学性质&存储条件

分子量	518.053
分子式	C28H32ClN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 5.3 mg/mL (Need warming)
Chemical Name/SMILES	Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]-

参考文献

1. Ong CC, et al. Breast Cancer Res. 2015 Apr 23;17:59.

2. Mortazavi F, et al. BMC Cancer. 2015 May 9;15:381.

3. Semenova G, et al. Oncogene. 2017 May 22. doi: 10.1038/onc.2017.143.

FRAX1036 (FRAX-1036, FRAX 1036)

生物&药学活性

物理化学性质&存储条件

参考文献

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FRAX1036 (FRAX-1036, FRAX 1036)

生物&药学活性

物理化学性质&存储条件

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