FR 180204 |CAS:865362-74-9 Probechem Biochemicals

Chemical Structure : FR 180204

CAS No.: 865362-74-9

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FR 180204 (FR180204;FR-180204)

货号: PC-42937Not For Human Use, Lab Use Only.

FR 180204 is a potent, selective, ATP-competitive ERK inhibitor with Ki of 0.31 and 0.14 uM for ERK1 and ERK2, respectively.

规格	价格	库存
5 mg	￥850	In stock
10 mg	￥1250	In stock
25 mg	￥1950	In stock
100 mg		Get quote

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生物&药学活性

FR 180204 is a potent, selective, ATP-competitive ERK inhibitor with Ki of 0.31 and 0.14 uM for ERK1 and ERK2, respectively.
FR 180204 inhibits TGFβ-induced luciferase-expression in mink lung epithelial Mv1Lu cells.
FR 180204 decreases plasma anti-CII antibody levels and attenuates delayed-type hypersensitivity in CII-immunized DBA/1 mice, also inhibits in vitro CII-induced proliferation of lymph node cells prepared from CII-immunized mice.
FR 180204 enhances apoptotic and anti-proliferative effects of Akt inhibitor API-1 in human DLD-1 and LoVo colorectal cancer cells.

物理化学性质&存储条件

分子量	327.3427
分子式	C18H13N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 50 mg/mL
Chemical Name/SMILES	1H-Pyrazolo[3,4-c]pyridazin-3-amine, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-

参考文献

1. Ohori M, et al. Biochem Biophys Res Commun. 2005 Oct 14;336(1):357-63.

2. Ohori M, et al. Naunyn Schmiedebergs Arch Pharmacol.

3. Chen-Roetling J, et al. Neuropharmacology. 2009 Apr;56(5):922-8.

4. Saglam AS, et al. Oncol Lett. 2016 Oct;12(4):2463-2474.

FR 180204 (FR180204;FR-180204)

生物&药学活性

物理化学性质&存储条件

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FR 180204 (FR180204;FR-180204)

生物&药学活性

物理化学性质&存储条件

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