FR173657 | B2R antagonist | Probechem Biochemicals

Chemical Structure : FR173657

加入收藏

FR173657 (FK-3657)

货号: PC-26638Not For Human Use, Lab Use Only.

FR173657 (FK-3657) is a potent, selective, orally active bradykinin B2 receptor (B2R) antagonist with IC50 of 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

FR173657 (FK-3657) is a potent, selective, orally active bradykinin B2 receptor (B2R) antagonist with IC50 of 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively.
FR173657 displaces[3H]-BK binding to B2 receptors with an IC50 of 2.9 nM and a Ki of 0.36 nM in human lung fibroblast IMR-90 cells.
FR173657 doess not reduce [3H]-des]Arg10-kallidin binding to B1 receptors.
FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED50: 0.075 mg/kg).
FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED50: 6.8 mg/kg).

物理化学性质&存储条件

分子量	592.48
分子式	C30H27Cl2N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(6-Acetamidopyridin-3-yl)-N-(2-((2,4-dichloro-3-(((2-methylquinolin-8-yl)oxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)acrylamide

参考文献

1. Asano M, et al. Br J Pharmacol. 1997 Feb;120(4):617-24.

FR173657 (FK-3657)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

FR173657 (FK-3657)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.