FR054 ((6R)-FR054 ) | PGM3 inhibitor | Probechem Biochemicals

Chemical Structure : FR054

CAS No.: 10378-06-0

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FR054 (FR-054, (6R)-FR054 )

货号: PC-49557Not For Human Use, Lab Use Only.

FR054 (FR-054) is a specific small molecule inhibitor of hexosamine biosynthetic pathway (HBP) enzyme N-Acetylglucosamine-phosphate Mutase (PGM3), shows a remarkable anti-breast cancer effect.

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10 mg	￥780	In stock
50 mg	￥1380	In stock
100 mg	￥2180	In stock
250 mg		Get quote

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生物&药学活性

FR054 (FR-054) is a specific small molecule inhibitor of hexosamine biosynthetic pathway (HBP) enzyme N-Acetylglucosamine-phosphate Mutase (PGM3), shows a remarkable anti-breast cancer effect.
FR054 enhanced the stability of PGM3 protein in a dose-dependent manner and with a more potent binding than the natural substrate GlcNAc-6-P.
FR054 induced an early proliferation arrest followed by a marked cell death increase in breast cancer cells.
FR054 (250 μM, 24 h) treatment efficiently affected both N- and O-glycosylation levels in MDA-MB-231 cells.
FR054 reduced MDA-MB-231 cell adhesion, migration, and integrin β1 membrane localization, induced ER stress and a ROS-dependent apoptotic cell death.
FR054 (1000 mg/kg, 10% DMSO) administered in single dose reduced tumor growth in nude mice xenograft model of TNBC cells MDA-MB-231.

物理化学性质&存储条件

分子量	329.30
分子式	C14H19NO8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-d-glucopyrano)-[2,1-d]-2-oxazoline

参考文献

1. Ricciardiello F, et al. Cell Death Dis. 2018 Mar 7;9(3):377.

2. Ricciardiello F, et al. Oncogene. 2020 May;39(20):4103-4117.

FR054 (FR-054, (6R)-FR054 )

生物&药学活性

物理化学性质&存储条件

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FR054 (FR-054, (6R)-FR054 )

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物理化学性质&存储条件

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