FQI2-34 | LSF-β-catenin inhibitor | Probechem Biochemicals

Chemical Structure : FQI2-34

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FQI2-34 (FQI 2-34)

货号: PC-22044Not For Human Use, Lab Use Only.

FQI2-34 is a small molecule inhibitor of late SV40 factor (LSF, encoded by TFCP2) and β-catenin interaction, suppresses Wnt activity in CRC cells.

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生物&药学活性

FQI2-34 is a small molecule inhibitor of late SV40 factor (LSF, encoded by TFCP2) and β-catenin interaction, specifically inhibits LSF DNA-binding, partner protein-binding, and transactivation activities, suppresses Wnt activity in CRC cells.
FQI2-34 at 1 μmol/L concentrations consistently reduced LSF–β-catenin interaction in different CRC cell lines.
FQI2-34 reduced colocalization of late SV40 factor (LSF) and β-catenin in colorectal cancer cell lines.
FQI2-34 (1-20 uM) inhibited Wnt activity in CRC cell lines irrespective of their Wnt status.
FQI2-34 suppressed β-catenin in both digitonin and nondigitonin fractions, decreased levels of cytosolic β-catenin in CRC cell lines.
FQI2-34 (5 mg/kg daily for 5 consecutive days each week). suppressed growth and Wnt targets in allogeneic colorectal cancer xenograft.

物理化学性质&存储条件

分子量	352.39
分子式	C20H20N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(4-(Dimethylamino)-2-Ethoxyphenyl)-[1,3]Dioxolo[4,5-g]Quinolin-6(5H)-One

参考文献

1. Lotfollahzadeh S, et al. Am J Pathol. 2022 Aug;192(8):1167-1185.

FQI2-34 (FQI 2-34)

生物&药学活性

物理化学性质&存储条件

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FQI2-34 (FQI 2-34)

生物&药学活性

物理化学性质&存储条件

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