FPTP

Chemical Structure : FPTP

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货号: PC-27196Not For Human Use, Lab Use Only.

FPTP is a pharmacological small-molecule NEK9 inhibitor with SPR KD of 3.64 uM, inhibits viability of Huh-7 and Hep3b cells with IC50 of 18.7 uM and 22.8 uM.

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生物&药学活性

FPTP is a pharmacological small-molecule NEK9 inhibitor with SPR KD of 3.64 uM, inhibits viability of Huh-7 and Hep3b cells with IC50 of 18.7 uM and 22.8 uM.
FPTP reduces NEK9 mRNA and protein levels in Huh-7 and Hep3b cells, NEK9 overexpression partially rescued the inhibitory effects of FPTP, but not NEK2 or NEK6.
FPTP suppresses NEK9-driven tumour growth and restore antitumour immunity in vivo, restores CD8+ T cell antitumour activity.
Combining FPTP with PD-L1 blocker CA-170 synergistically enhances antitumour immunity in HCC.

物理化学性质&存储条件

分子量	466.55
分子式	C27H26N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-isopropylphenyl)-2-methyl-N-(2-(5-(pyridin-4-yl)-1,2,4-oxadiazol-3-yl)ethyl)-1H-benzo[d]imidazole-5-carboxamide

参考文献

1. Lu G, et al. Gut. 2026 Jun 25:gutjnl-2026-338449.

FPTP

生物&药学活性

物理化学性质&存储条件

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FPTP

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物理化学性质&存储条件

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