FPR agonist Compound 43 | FPR agonist | Probechem Biochemicals

Chemical Structure : FPR agonist Compound 43

CAS No.: 903895-98-7

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FPR agonist Compound 43 (FPR agonist Cmpd43, Compound 43)

货号: PC-72086Not For Human Use, Lab Use Only.

FPR agonist Compound 43 is a potent agonist of human formyl-peptide-like 1 receptor (hFPRL1) with EC50 of 44 nM (hFPRL1-mediated Ca2+ mobilization).

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5 mg	￥1480	In stock
10 mg	￥2380	In stock
25 mg	￥3980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FPR agonist Compound 43 is a potent agonist of human formyl-peptide-like 1 receptor (hFPRL1, FPR2) with EC50 of 44 nM (hFPRL1-mediated Ca2+ mobilization).
FPR agonist Compound 43 inhibited neutrophil (PMN) migration with IC50 of 1 uM.
FPR agonist Compound 43 showed a dose-dependent inhibition of ear swelling in mice following oral administration.

物理化学性质&存储条件

分子量	384.864
分子式	C20H21ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-chlorophenyl)-3-(5-isopropyl-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)urea

参考文献

1. Cheng Xue Qin, et al. Nat Commun. 2017 Feb 7;8:14232.

2. Agostino Cilibrizzi, et al. J Med Chem. 2009 Aug 27;52(16):5044-57.

3. Crocetti L, et al. Molecules. 2021 Oct 30;26(21):6583.

4. Roland W Bürli, et al. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3713-8.

FPR agonist Compound 43 (FPR agonist Cmpd43, Compound 43)

生物&药学活性

物理化学性质&存储条件

参考文献

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FPR agonist Compound 43 (FPR agonist Cmpd43, Compound 43)

生物&药学活性

物理化学性质&存储条件

参考文献

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