FPPS inhibitor OX14 | 1219126-87-0 | Probechem Biochemicals

Chemical Structure : FPPS inhibitor OX14

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FPPS inhibitor OX14 (OX14)

货号: PC-61730Not For Human Use, Lab Use Only.

OX14 is a highly potent farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 of 2.46 nM, with significantly lower binding affinity to hydroxyapatite.

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生物&药学活性

OX14 is a highly potent farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 of 2.46 nM, with significantly lower binding affinity to hydroxyapatite.
OX14 inhibits bone resorption, significantly prevents the formation of osteolytic lesions in JJN3-NSG murine model of myeloma-induced bone disease.
OX14 is a new, highly potent bisphosphonate with lower bone binding affinity than other clinically relevant bisphosphonates.

物理化学性质&存储条件

分子量	324.141
分子式	C9H11FN2O6P2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1-fluoro-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)bis(phosphonic acid)

参考文献

1. Lawson MA, et al. J Bone Miner Res. 2017 Sep;32(9):1860-1869.

FPPS inhibitor OX14 (OX14)

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物理化学性质&存储条件

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FPPS inhibitor OX14 (OX14)

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