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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ROCK-FPND
FPND

Chemical Structure : FPND

CAS No.: 924866-33-1

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FPND (FPMINT)

货号: PC-61252Not For Human Use, Lab Use Only.

FPND (FPMINT) is a novel specific ROCK1 kinase inhibitor with IC50 of 11.2 uM, without inhibitory activity against ROCK2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    FPND (FPMINT) is a novel specific ROCK1 kinase inhibitor with IC50 of 11.2 uM, without inhibitory activity against ROCK2.
    FPND (FPMINT) prevents atorvastatin-induced cerebral hemorrhage in zebrafish embryos (IC50=17.49 uM), by enhancing endothelial cell-cell junctions through inhibiting the ROCK-mediated VE-cadherin signaling pathway.
    FPMINT is a potent equilibrative nucleoside transporters (ENTs) inhibitor, more selective to ENT2 than to ENT1.
     

    物理化学性质&存储条件

    分子量 429.503
    分子式 C24H24FN7
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-[4-(2-fluorophenyl)-1-piperazinyl]methyl-N-1-naphthyl-1,3,5-triazine-2,4-diamine

    参考文献

    1. Li S, et al. Cell Death Discov. 2017 Aug 21;3:17051.
    2. Renkai Li, et al. Front Pharmacol. 2022 Feb 21;13:837555.

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