FPD5

Chemical Structure : FPD5

加入收藏

货号: PC-23540Not For Human Use, Lab Use Only.

FPD5 is a small molecule activator of esterase D (ESD) with KD value of 0.8 nM, directly binds to ESD at Lys180 rather than its ubiquitination site Lys213.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

FPD5 is a small molecule activator of esterase D (ESD) with KD value of 0.8 nM, directly binds to ESD at Lys180 rather than its ubiquitination site Lys213.
FPD5 increases ESD activity with FPD5 at 0.1 μM and 1 μM for 24 h in L-02 cells.
FPD5 promotes ESD mono-ubiquitination in HEK293T cells.
Mutations K180A and K213A inhibited the interaction of FPD5 and ESD.
FPD5 inhibits cancer cell growth by arresting the cell cycle of A549 cells via the JAB1/p53 signaling pathway.

物理化学性质&存储条件

分子量	349.82
分子式	C20H16ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-2-(5-phenyl-1-(pyridin-2-yl)-4, 5-dihydro-1H-pyrazol-3-yl) phenol

参考文献

1. Chen X, et al. Bioorg Med Chem Lett. 2020 Jun 1;30(11):127150.

2. Yao W, et al. Genes (Basel). 2022 Apr 28;13(5):786.

FPD5

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

FPD5

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.