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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-FP802
FP802

Chemical Structure : FP802

CAS No.: 61694-81-3

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FP802 (FP 802, FP-802)

货号: PC-21854Not For Human Use, Lab Use Only.

FP802 is a potent neuroprotectant and small molecule inhibitor of TwinF interface, shows selective elimination of eNMDAR-mediated toxicity via disruption of the NMDAR/TRPM4 death signaling complex, while sparing the vital physiological functions of synaptic NMDARs.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    FP802 is a potent neuroprotectant and small molecule inhibitor of TwinF interface, shows selective elimination of eNMDAR-mediated toxicity via disruption of the NMDAR/TRPM4 death signaling complex, while sparing the vital physiological functions of synaptic NMDARs.
    FP802 displays potent protective activity against glutamate-mediated neurotoxicity with IC50 of 8.7 uM for analysis of the percentage of nuclear mCherry-positive neurons.
    FP802 eliminates the transcriptional shut-off induced by eNMDARs and boosts the NMDA bath application-induced expression of the immediate-early genes (IEGs) Atf3, Arc, Bdnf, cFos, Inhibin beta A, and Npas4.
    FP802 does not not block NMDARs expressed heterologously in HEK293 cells (IC50 > 250 μM for both, GluN1/GluN2A and GluN1/GluN2B).
    FP802 (40 mg/kg/day) improves motor performances, extends lifespan, and prevents motor neuron loss in SOD1G93A mice.
    FP802 protects human brain organoids generated using iPSCs from ALS patients or healthy controls against NMDA-induced neurotoxicity.

    物理化学性质&存储条件

    分子量 212.72
    分子式 C11H17ClN2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1-(3-chlorobenzyl)-N1-ethylethane-1,2-diamine

    参考文献

    1. Jing Yan, et al. Cell Rep Med. 2024 Feb 20;5(2):101413.

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