FOXO1-IN-10 | FOXO1 inhibitor | Probechem Biochemicals

Chemical Structure : FOXO1-IN-10

CAS No.: 2451093-95-9

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FOXO1-IN-10 (FOXO1 inhibitor Compound 10)

货号: PC-49398Not For Human Use, Lab Use Only.

FOXO1-IN-10 (FOXO1 inhibitor 10) is a highly selective small molecule inhibitor of transcription factor FOXO1 with IC50 of 0.21 and 0.03 uM for hFOXO1 and mFOXO1, respectively.

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1 mg	￥1580	In stock
5 mg	￥3280	In stock
10 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FOXO1-IN-10 (FOXO1 inhibitor 10) is a highly selective small molecule inhibitor of transcription factor FOXO1 with IC50 of 0.21 and 0.03 uM for hFOXO1 and mFOXO1, respectively.
FOXO1-IN-10 induces a robust cytotoxic response of mantle cell lymphoma (MCL) cells in vitro and suppresses MCL progression in vivo.
FOXO1-IN-10 is highly selective for FOXO1 both in vitro and in vivo and fails to elicit any effect in genetic models of FOXO1 ablation.
Chronic administration of FOXO1-IN-10 improved insulin sensitivity and glucose control in db/db mice without causing weight gain.
Chronic FOXO1-IN-10 treatment combined with FGF21 led to synergistic glucose lowering in lean, streptozotocin-induced diabetic mice.

物理化学性质&存储条件

分子量	401.474
分子式	C22H23N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazol-5-yl)-4-(4-methylpiperazin-1-yl)benzamide

参考文献

1. Langlet F, et al. Cell. 2017 Nov 2;171(4):824-835.e18.

2. Ja-Young Jang, et al. J Clin Invest. 2022 Oct 25;e160767.

3. Yun-Kyoung Lee, et al. Mol Metab. 2021 Jul;49:101187.

FOXO1-IN-10 (FOXO1 inhibitor Compound 10)

生物&药学活性

物理化学性质&存储条件

参考文献

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FOXO1-IN-10 (FOXO1 inhibitor Compound 10)

生物&药学活性

物理化学性质&存储条件

参考文献

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