FOXM1 inhibitor RCM-1 | FOXM1 inhibitor | Probechem Biochemicals

Chemical Structure : FOXM1 inhibitor RCM-1

CAS No.: 339163-65-4

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FOXM1 inhibitor RCM-1 (Robert Costa Memorial drug-1, RCM-1)

货号: PC-72976Not For Human Use, Lab Use Only.

FOXM1 inhibitor RCM-1 (Robert Costa Memorial drug-1, RCM-1) is a small molecule potent inhibitor of FOXM1 transcription factor.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FOXM1 inhibitor RCM-1 (Robert Costa Memorial drug-1, RCM-1) is a small molecule potent inhibitor of FOXM1 transcription factor.
RCM-1 inhibited the nuclear localization of FOXM1 protein, increased its ubiquitination and caused degradation of FOXM1 in proteasome.
RCM-1 reduced airway resistance, increased lung compliance, and decreased proinflammatory cytokine production in mice exposed to the house dust mite and interleukin-13 (IL-13), which triggers goblet cell metaplasia.
RCM-1 reduced the formation and growth of tumor cell colonies in the colony formation assay.
In animal models, RCM-1 treatment inhibited growth of mouse rhabdomyosarcoma Rd76-9, melanoma B16-F10, and human H2122 lung adenocarcinoma.
RCM-1 decreased FOXM1 protein in the tumors, reduced tumor cell proliferation, and increased tumor cell apoptosis.
RCM-1 decreased protein levels and nuclear localization of β-catenin, and inhibited protein-protein interaction between β-catenin and FOXM1 in cultured tumor cells and in vivo.

物理化学性质&存储条件

分子量	424.58
分子式	C20H12N2OS4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-Oxo-2-(thiophen-2-yl)ethyl)thio)-4,6-di(thiophen-2-yl)nicotinonitrile

参考文献

1. Lifeng Sun, et al. Sci Signal. 2017 Apr 18;10(475):eaai8583.

2. Samriddhi Shukla, et al. Mol Cancer Ther. 2019 Jul;18(7):1217-1229.

FOXM1 inhibitor RCM-1 (Robert Costa Memorial drug-1, RCM-1)

生物&药学活性

物理化学性质&存储条件

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FOXM1 inhibitor RCM-1 (Robert Costa Memorial drug-1, RCM-1)

生物&药学活性

物理化学性质&存储条件

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