FOXM1 inhibitor NB-55 |FOXM1 inhibitor | Probechem Biochemicals

Chemical Structure : FOXM1 inhibitor NB-55

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FOXM1 inhibitor NB-55 (NB-55)

货号: PC-20009Not For Human Use, Lab Use Only.

FOXM1 inhibitor NB-55 is a small molecule inhibitor of transcription factor FOXM1 with Ki value of 230 nM and IC50 of 1.24 uM, bind directly to FOXM1 and alter its proteolytic sensitivity, reduces the cellular level of FOXM1 protein.

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生物&药学活性

FOXM1 inhibitor NB-55 is a small molecule inhibitor of transcription factor FOXM1 with Ki value of 230 nM and IC50 of 1.24 uM, bind directly to FOXM1 and alter its proteolytic sensitivity, reduces the cellular level of FOXM1 protein.
NB-55 suppresses breast cancer cell proliferation and cell cycle progression and increase apoptosis.
NB-55 decreases expression of FOXM1-regulated genes and suppress gene ontologies under FOXM1 regulation.

物理化学性质&存储条件

分子量	504.16
分子式	C33H42ClNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[6-[4-[(4-Chlorophenyl)tricyclo[3.3.1.13,7]dec-2-ylidenemethyl]phenoxy]hexyl]pyrrolidine

参考文献

1. Parama Dey, et al. Cancers (Basel). 2020 Sep 19;12(9):2677.
2. Ipshita Nandi, et al. J Clin Invest. 2023 Apr 3;133(7):e162324.
3. Yvonne Ziegler, et al. NPJ Breast Cancer. 2019 Nov 29;5:45.

FOXM1 inhibitor NB-55 (NB-55)

生物&药学活性

物理化学性质&存储条件

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FOXM1 inhibitor NB-55 (NB-55)

生物&药学活性

物理化学性质&存储条件

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