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首页-小分子抑制剂&激动剂-GPCR-mGluR-FO-4-15
FO-4-15

Chemical Structure : FO-4-15

CAS No.: 1030202-26-6

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FO-4-15

货号: PC-22952Not For Human Use, Lab Use Only.

FO-4-15 is a small molecule taregting mGluR1 with low cytotoxicity and anti-H2O2 effect, significantly reduces Aβ accumulation, Tau hyper-phosphorylation, and synaptic impairments in 3×Tg mice, activates mGluR1/CaMKIIα pathway.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

FO-4-15 is a small molecule taregting mGluR1 with low cytotoxicity and anti-H2O2 effect, significantly reduces Aβ accumulation, Tau hyper-phosphorylation, and synaptic impairments in 3×Tg mice, activates mGluR1/CaMKIIα pathway.

物理化学性质&存储条件

分子量 424.48
分子式 C21H20N4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(furan-2-yl)-5-((4-(naphthalen-2-ylsulfonyl)piperazin-1-yl)methyl)-1,2,4-oxadiazole

参考文献

1. Luo ZH, et al. Acta Pharmacol Sin. 2024 Aug 16. doi: 10.1038/s41401-024-01362-0.

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