FMP-201300 | IP6K inhibitor | Probechem Biochemicals

Chemical Structure : FMP-201300

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FMP-201300 (FMP201300)

货号: PC-21232Not For Human Use, Lab Use Only.

FMP-201300 is a potent, selective and allosteric inhibitor of the unique valine gatekeeper mutants of IP6K1 and IP6K2 with IC50 of 114/190 nM for IP6K1 L210V and IP6K2 L210V mutants respectively.

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生物&药学活性

FMP-201300 is a potent, selective and allosteric inhibitor of the unique valine gatekeeper mutants of IP6K1 and IP6K2 with IC50 of 114/190 nM for IP6K1 L210V and IP6K2 L210V mutants respectively.
FMP-201300 binds to an allosteric pocket adjacent to the ATP binding site.
FMP-201300 shows no known inhibitory activities against other biological targets and does not display any recognized PAINS motifs.
FMP-201300 is neither redox-active, nor cytotoxic, against HEK293 or HepG2 cell lines at a concentration of 10 µM.

物理化学性质&存储条件

分子量	572.49
分子式	C31H16N4O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(6-(5-carboxy-1,3-dioxoisoindolin-2-yl)-1H-benzo[d]imidazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid

参考文献

1. Aguirre T, et al. Elife. 2023 Oct 16;12:RP88982.

FMP-201300 (FMP201300)

生物&药学活性

物理化学性质&存储条件

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FMP-201300 (FMP201300)

生物&药学活性

物理化学性质&存储条件

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